Men’s health is indeed often the forgotten dimension of healthcare conditions, and erectile dysfunction (ED) is one of those. It not only influences the patient’s well-being but the quality of life as well. Despite the fact it is one of the most pronounced problems in our society, it is not one to be talked about with an air of openness.

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While the forthcoming developments in medicine have provided effective solutions that are destined to solve this controversial problem, it has left a lot of controversies among people. Over drugs and other alternatives to medical therapy, certain prescription medications have proven themselves as the lead medical remedy among the treatments of the ED, for instance, Kamagra Gold 100, Fildena 100 mg, and so on. 

This article aims to be a source of information in regards to the most popular of these treatments, therefore providing you with the outcomes achieved in them, promising to lead you to the freedom you need.

The Chronicles Of ED Treatments

Choosing the best erectile dysfunction medicine is certainly not a cakewalk because it’s an entire process that demands closer inspection of multiple aspects. For instance, first the detection of symptoms, diagnosis of the condition, inspection of root problems, deciding on dosage, checking drug interactions, considering side effects, and so on. 

If you have fixed the one you want, visit Medixpills to find Super P Force, Hiforce 100 mg, and many more.

Moreover, there are different medication options like ayurvedic, allopathic, homeopathic, and so on makes the process even more complex. So let’s go consider some of the best erectile dysfunction medicines that are evergreen, effective, and usually well-tolerated by everyone (we mean men). 

What Is The Safest Drug For Erectile Dysfunction?

It’s like picking one fish from the stream of hundreds and thousands of fish. The drugs are out there but you need to pick one that works best for you. However, in this picking procedure, you need to have a clear understanding of certain things like medical history. 

Only a professional medical practitioner can help you here unless you are one yourself. If you are not, try not to be one. Just confer to your nearest or your family doctor. 

How Do Ed Medications Work?

The steps that ED-meds’ (or should I say PDE5 inhibitors) working mechanism follows are very mesmerizing activity. Here we have explained them in a hop-by-hop way. Remember these erectile dysfunction medicines; Nizagara 100, and Malegra 100 are purely helpful for supporting your dick to stand correctly but not to make you feel aroused. 

  • They function via inhibition of enzyme PDE5, which is responsible for the conversion of cyclic guanosine monophosphate (cGMP) to its phosphoric derivatives (PGP). 
  • cGMP is an element, that works by calming and widening blood vessels and smooth muscle cells. This promotes the enlargement of the phallus by the enhanced blood flow to the penis. 
  • Nitric oxide, being a kind of organic compound, is produced in quantities in the penis upon sexual stimulation.
  • Nitric oxide serves as the precursor to the production of cGMP that governs the supple muscle at the blood vessels responsible for the inflow and outflow of blood through the penis.
  • Through the blockade of PDE5, these effective ED medications extend the effects of NO, hence increasing the volume of blood that flows to the penis resulting in erection when there is sexual stimulation. 

Can They Counter Sexual Performance Anxiety And Stress?

Now this is the very frequently asked question alongside whether these erectile dysfunction medications also give you arousal. But for both questions, the unfortunate answer is no. 

However, if you see it from another angle it might somewhat be true. Since these ED prescription drugs facilitate firmer-harder erections, the confidence in your bed might be roused. Hence, it will calm down your anxiety and also brush up your sexual performance

How do you break the performance anxiety cycle

The List Of Best Ed Drugs

Although we are providing you with some of the well-known and best erectile dysfunction solutions, don’t just trust them blindly. Give equal thought to other alternatives as well, like over-the-counter or home erectile dysfunction remedies

So let’s begin with Top ED treatments. 


Sildenafil citrate is the oldest and eldest of all PDE-5 inhibitors. It is precisely the expert, cGMP-specific PDE5 inhibitor. Sildenafil citrate, Viagra’s trade name, is frequently given to men to treat limp dick symptoms. Examples are Cenforce 100mg and Cenforce 150 mg

When marketed as Revatio, it intends to cure pulmonary arterial hypertension (PAH) and enhance the health status of all genders through physical activity.

Moreover, sildenafil is also remarked as a ‘fortunate accident’. The original intention of the drug was to treat PAH only but surprisingly it killed two birds with one stone.

Read more>>> Can You Take Viagra With Blood Pressure Medicine?


Tadalafil, the active component of Cialis, was invented by Glaxo Wellcome thanks to collaboration with ICOS, one more pharmaceutical company, whose task was to discover new drugs for these two companies that started in August 1991. 

When sildenafil proved to be effective, researchers started the program of developing more drugs of the same type. And it was at that time that they found out about the second product, i.e, Tadalafil. Examples are Vidalista 20 mg and Vidalista Black 80mg

Also Read>>> Cialis vs Viagra: What’s The Difference?


Mitsubishi Tanabe Pharma manufactures Avanafil, a PDE5 inhibitor that the FDA approved for treating erectile dysfunction on April 27, 2012. The EMA then recognized and marketed it on June 21, 2013, under the trade names Stendra and Spedra. Like ICOS, Mitsubishi Tanabe Pharma conducts research and development.  

Since the FDA approved sildenafil, manufacturers have significantly improved these erectile dysfunction medicines, and these advancements are commendable.


Vardenafil’s indications and contraindications are similar to other PDE5 inhibitors, but as is the case with sildenafil citrate (Viagra) and tadalafil (Cialis) it performs the same action in the body. What separates vardenafil from sildenafil is the position of what their molecules do at the nitrogen atom. 

The pharmacological activity of tadalafil makes tadalafil different from both sildenafil and vardenafil. Vardenafil is comparable to and a little longer than sildenafil in terms of active time.  

Furthermore, vardenafil does not affect PDE6, so it lacks the adverse effects on vision. Another advantage of this drug is thus that it does not affect the vision like the chemotherapeutic agents. 

In addition to its applications in ED medicine, vardenafil has been shown to produce a positive effect of at least doubling the time between penetration and ejaculation. The best example is Vilitra 20.

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